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Automated craniofacial biometry with 3D T2w fetal MRI

Author

Listed:
  • Jacqueline Matthew
  • Alena Uus
  • Alexia Egloff Collado
  • Aysha Luis
  • Sophie Arulkumaran
  • Abi Fukami-Gartner
  • Vanessa Kyriakopoulou
  • Daniel Cromb
  • Robert Wright
  • Kathleen Colford
  • Maria Deprez
  • Jana Hutter
  • Jonathan O’Muircheartaigh
  • Christina Malamateniou
  • Reza Razavi
  • Lisa Story
  • Joseph V Hajnal
  • Mary A Rutherford

Abstract

Objectives: Evaluating craniofacial phenotype-genotype correlations prenatally is increasingly important; however, it is subjective and challenging with 3D ultrasound. We developed an automated label propagation pipeline using 3D motion- corrected, slice-to-volume reconstructed (SVR) fetal MRI for craniofacial measurements. Methods: A literature review and expert consensus identified 31 craniofacial biometrics for fetal MRI. An MRI atlas with defined anatomical landmarks served as a template for subject registration, auto-labelling, and biometric calculation. We assessed 108 healthy controls and 24 fetuses with Down syndrome (T21) in the third trimester (29–36 weeks gestational age, GA) to identify meaningful biometrics in T21. Reliability and reproducibility were evaluated in 10 random datasets by four observers. Results: Automated labels were produced for all 132 subjects with a 0.3% placement error rate. Seven measurements, including anterior base of skull length and maxillary length, showed significant differences with large effect sizes between T21 and control groups (ANOVA, p

Suggested Citation

  • Jacqueline Matthew & Alena Uus & Alexia Egloff Collado & Aysha Luis & Sophie Arulkumaran & Abi Fukami-Gartner & Vanessa Kyriakopoulou & Daniel Cromb & Robert Wright & Kathleen Colford & Maria Deprez &, 2024. "Automated craniofacial biometry with 3D T2w fetal MRI," PLOS Digital Health, Public Library of Science, vol. 3(12), pages 1-27, December.
    • Handle: RePEc:plo:pdig00:0000663
    DOI: 10.1371/journal.pdig.0000663
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